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Article

Comprehensive molecular profiling of advanced/metastatic olfactory neuroblastomas.

PloS one - 1 Jan 2018

Topcagic Jasmina, Feldman Rebecca, Ghazalpour Anatole, Swensen Jeffrey, Gatalica Zoran, Vranic Semir

Abstract excerpt

Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and there are no specific treatment guidelines for recurrent/metastatic ONBs. This study retrospectively evaluated 23 ONB samples profiled at Caris Life Sciences (Phoenix, Arizona) using DNA sequencing (Sanger/NGS [Illumina], n = 15)...

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Topics

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Share to DNA Copy Number Variations
Share to DNA, Neoplasm
Share to Gene Fusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Molecular Targeted Therapy

Share to Nasal Cavity

Share to Neoplasm Recurrence, Local

Share to Nose Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 29324814
DOI: 10.1371/journal.pone.0191244
PMCID: PMC5764485

Genes

EGFR
PDGFRA
APC
CDH1
CTNNB1
ERCC1
SCG2
SMAD4
TUBB3

Provenance

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