Article
Phenotypic characteristics of colorectal cancer in BRCA1/2 mutation carriers.
European journal of human genetics : EJHG - 1 Mar 2018
Grinshpun Albert, Halpern Naama, Granit Roy Zvi, Hubert Ayala, Hamburger Tamar, Laitman Yael, Shacham-Shmueli Einat, Peerless Yehudit, Friedman Eitan, Peretz Tamar
Abstract excerpt
Mutations in the BRCA1/2 genes were recently shown to be associated with an increased risk for colorectal cancer. We characterized the largest cohort available of BRCA1/2 mutation carriers with colorectal cancer. We analyzed 32 patients with lower gastrointestinal cancers and germline BRCA1/2 mutations from two large academic hospital registries; 91% of patients were of Ashkenazi ancestry, 78% were women, and...
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