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Article

Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82

1 Jan 2018

Abstract excerpt

Here, we find that human-induced pluripotent stem cell (hiPSC)-derived cardiomyocyte (CM)-fated progenitors (CFPs) that express a tetraspanin family glycoprotein, CD82, almost exclusively differentiate into CMs both in vitro and in vivo . CD82 is transiently expressed in late-stage mesoderm cells during hiPSC differentiation. Purified CD82 + cells gave rise to CMs under nonspecific in vitro culture conditions...

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PMID: 29320747
DOI: 10.1016/j.celrep.2017.12.057

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