Article
Genetic alterations and tumor immune attack in Yo paraneoplastic cerebellar degeneration.
Acta neuropathologica - 1 Apr 2018
Small Mathilde, Treilleux Isabelle, Couillault Coline, Pissaloux Daniel, Picard Géraldine, Paindavoine Sandrine, Attignon Valery, Wang Qing, Rogemond Véronique, Lay Stéphanie, Ray-Coquard Isabelle, Pfisterer Jacobus, Joly Florence, Du Bois Andreas, Psimaras Dimitri, Bendriss-Vermare Nathalie, Caux Christophe, Dubois Bertrand, Honnorat Jérôme, Desestret Virginie
Abstract excerpt
Paraneoplastic cerebellar degenerations with anti-Yo antibodies (Yo-PCD) are rare syndromes caused by an auto-immune response against neuronal antigens (Ags) expressed by tumor cells. However, the mechanisms responsible for such immune tolerance breakdown are unknown. We characterized 26 ovarian carcinomas associated with Yo-PCD for their tumor immune contexture and genetic status of the 2 onconeural Yo-Ags, CDR2...
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