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Article

Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations.

BMC cancer - 3 Jan 2018

Hollis Robert L, Meynert Alison M, Churchman Michael, Rye Tzyvia, Mackean Melanie, Nussey Fiona, Arends Mark J, Sims Andrew H, Semple Colin A, Herrington C Simon, Gourley Charlie

Abstract excerpt

BACKGROUND: Approximately 10-15% of ovarian carcinomas (OC) are attributed to inherited susceptibility, the majority of which are due to mutations in BRCA1 or BRCA2 (BRCA1/2). These patients display superior clinical outcome, including enhanced sensitivity to platinum-based chemotherapy. Here, we seek to investigate whether BRCA1/2 status influences the response rate to single-agent pegylated liposomal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29298688
DOI: 10.1186/s12885-017-3981-2
PMCID: PMC5753521

Genes

BRCA1
BRCA2
HGS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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