Article
Dose-Duration Reciprocity for G protein activation: Modulation of kinase to substrate ratio alters cell signaling.
PloS one - 1 Jan 2017
Liao Kang-Ling, Melvin Charles E, Sozzani Rosangela, Jones Roger D, Elston Timothy C, Jones Alan M
Abstract excerpt
In animal cells, activation of heterotrimeric G protein signaling generally occurs when the system's cognate signal exceeds a threshold, whereas in plant cells, both the amount and the exposure time of at least one signal, D-glucose, are used toward activation. This unusual signaling property called Dose-Duration Reciprocity, first elucidated in the genetic model Arabidopsis thaliana, is achieved by a complex...
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