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Microbiota dysbiosis in inflammatory bowel diseases: in silico investigation of the oxygen hypothesis

1 Dec 2017

Abstract excerpt

BACKGROUND: Inflammatory bowel diseases (IBD), which include ulcerative colitis and Crohn's disease, cause chronic inflammation of the digestive tract in approximately 1.6 million Americans. A signature of IBD is dysbiosis of the gut microbiota marked by a significant reduction of obligate anaerobes and a sharp increase in facultative anaerobes. Numerous experimental studies have shown that IBD is strongly...

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PMID: 29282051
DOI: 10.1186/s12918-017-0522-1

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