Article
A comparison of genotyping-by-sequencing analysis methods on low-coverage crop datasets shows advantages of a new workflow, GB-eaSy.
BMC bioinformatics - 28 Dec 2017
Wickland Daniel P, Battu Gopal, Hudson Karen A, Diers Brian W, Hudson Matthew E
Abstract excerpt
BACKGROUND: Genotyping-by-sequencing (GBS), a method to identify genetic variants and quickly genotype samples, reduces genome complexity by using restriction enzymes to divide the genome into fragments whose ends are sequenced on short-read sequencing platforms. While cost-effective, this method produces extensive missing data and requires complex bioinformatics analysis. GBS is most commonly used on crop plant...
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