Article
Association of FLG single nucleotide variations with clinical phenotypes of atopic dermatitis.
PloS one - 1 Jan 2017
Kim Myungshin, Yoo Jaeeun, Kim Jiyeon, Park Joonhong, Han Eunhee, Jang Woori, Chae Hyojin, Lee Ji Hyun, Park Young Min, Kim Yonggoo
Abstract excerpt
BACKGROUND: FLG encodes a large protein called profilaggrin, which plays a key role in maintaining an effective skin barrier against the environment. In this study, we identified FLG single nucleotide variations (FLG-SNVs) and evaluated the association of FLG-SNVs with clinical phenotypes including atopic dermatitis (AD)-associated minor clinical features, presence of specific allergic sensitization, and serum...
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