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Article

Germ-line and somatic EPHA2 coding variants in lens aging and cataract.

PloS one - 1 Jan 2017

Bennett Thomas M, M'Hamdi Oussama, Hejtmancik J Fielding, Shiels Alan

Abstract excerpt

Rare germ-line mutations in the coding regions of the human EPHA2 gene (EPHA2) have been associated with inherited forms of pediatric cataract, whereas, frequent, non-coding, single nucleotide variants (SNVs) have been associated with age-related cataract. Here we sought to determine if germ-line EPHA2 coding SNVs were associated with age-related cataract in a case-control DNA panel (> 50 years) and if somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29267365
DOI: 10.1371/journal.pone.0189881
PMCID: PMC5739433

Genes

EPHA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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