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Integrating genome-wide association study summaries and element-gene interaction datasets identified multiple associations between elements and complex diseases.

Genetic epidemiology - 1 Mar 2018

He Awen, Wang Wenyu, Prakash N Tejo, Tinkov Alexey A, Skalny Anatoly V, Wen Yan, Hao Jingcan, Guo Xiong, Zhang Feng

Abstract excerpt

Chemical elements are closely related to human health. Extensive genomic profile data of complex diseases offer us a good opportunity to systemically investigate the relationships between elements and complex diseases/traits. In this study, we applied gene set enrichment analysis (GSEA) approach to detect the associations between elements and complex diseases/traits though integrating element-gene interaction...

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PMID: 29265413
DOI: 10.1002/gepi.22106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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