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Article

Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice.

Transgenic research - 1 Feb 2018

Smirnov Alexander V, Kontsevaya Galina V, Feofanova Natalia A, Anisimova Margarita V, Serova Irina A, Gerlinskaya Lyudmila A, Battulin Nariman R, Moshkin Mikhail P, Serov Oleg L

Abstract excerpt

Contactins (Cntn1-6) are a family of neuronal membrane proteins expressed in the brain. They are required for establishing cell-to-cell contacts between neurons and for the growth and maturation of the axons. In humans, structural genomic variations in the Contactin genes are implicated in neurodevelopmental disorders. In addition, population genetic studies associate Contactins loci with obesity and...

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PMID: 29264679
DOI: 10.1007/s11248-017-0053-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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