Article
In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2024
Du Samuel W, Newby Gregory A, Salom David, Gao Fangyuan, Menezes Carolline Rodrigues, Suh Susie, Choi Elliot H, Chen Paul Z, Liu David R, Palczewski Krzysztof
Abstract excerpt
Rhodopsin, the prototypical class-A G-protein coupled receptor, is a highly sensitive receptor for light that enables phototransduction in rod photoreceptors. Rhodopsin plays not only a sensory role but also a structural role as a major component of the rod outer segment disc, comprising over 90% of the protein content of the disc membrane. Mutations in RHO which lead to structural or functional abnormalities,...
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