Article
[The influence of chorionic gonadotropin on phenotype conversion and hTERT gene expression by T-lymphocytes of different degrees of differentiation].
Biomeditsinskaia khimiia - 1 Nov 2017
Rayev M B, Zamorina S A, Litvinova L S, Yurova K A, Khaziakhmatova O G, Timganova V P, Bochkova M S, Kropaneva M D, Khramtsov P V
Abstract excerpt
The effects of chorionic gonadotropin (hCG) on the expression of the hTERT gene in combination with the conversion of the phenotype of naive T-cells and T-cells of immune memory in vitro were studied. hCG inhibited expression of hTERT mRNA in naive T-cells (CD45RA+) and immune memory T cells (CD45RO+), causing a decrease in the replicative potential of the cells. The presence of hCG in the culture led to the...
Topics
- Cell Differentiation
- Cells, Cultured
- Chorionic Gonadotropin
- Female
- Humans
- Leukocyte Common Antigens
- Phenotype
- Pregnancy
- T-Lymphocytes
- Telomerase