Disruption of Interneuron Neurogenesis in Premature Newborns and Reversal with Estrogen Treatment

Abstract excerpt

Many Preterm-born children suffer from neurobehavioral disorders. Premature birth terminates the hypoxicin uteroenvironment and supply of maternal hormones. As the production of interneurons continues until the end of pregnancy, we hypothesized that premature birth would disrupt interneuron production and that restoration of the hypoxic milieu or estrogen treatment might reverse interneuron generation. To test...

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