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Article

Fibrin hydrogels as a xenofree and rapidly degradable support for transplantation of retinal pigment epithelium monolayers.

Acta biomaterialia - 1 Feb 2018

Gandhi Jarel K, Manzar Zahid, Bachman Lori A, Andrews-Pfannkoch Cynthia, Knudsen Travis, Hill Matthew, Schmidt Hannah, Iezzi Raymond, Pulido Jose S, Marmorstein Alan D

Abstract excerpt

Recent phase 1 trials of embryonic stem cell and induced pluripotent stem cell (iPSCs) derived RPE transplants for the treatment of macular degeneration have demonstrated the relative safety of this process. However, there is concern over clumping, thickening, folding, and wrinkling of the transplanted RPE. To deliver a flat RPE monolayer, current phase 1 trials are testing synthetic substrates for RPE...

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Identifiers

PMID: 29233750
DOI: 10.1016/j.actbio.2017.11.058

Genes

RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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