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Article

New therapeutic targets in transfusion-dependent and -independent thalassemia.

Hematology. American Society of Hematology. Education Program - 8 Dec 2017

Cappellini M Domenica, Motta Irene

Abstract excerpt

β-Thalassemias are characterized by reduced production of β-globin chain, resulting in α/β-chain unbalance and precipitation of α-globin-heme complexes and determining ineffective erythropoiesis. Ineffective erythropoiesis, chronic hemolytic anemia, and compensatory hematopoietic expansion are the disease hallmarks, and they are related to the severity of the chain unbalance. Several clinical forms of...

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Source

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Identifiers

PMID: 29222267
DOI: 10.1182/asheducation-2017.1.278
PMCID: PMC6142569

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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