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Article

Resistance analysis in patients with genotype 1-6 HCV infection treated with sofosbuvir/velpatasvir in the phase III studies.

Journal of hepatology - 1 May 2018

Hezode Christophe, Reau Nancy, Svarovskaia Evguenia S, Doehle Brian P, Shanmugam Ragavi, Dvory-Sobol Hadas, Hedskog Charlotte, McNally John, Osinusi Anu, Brainard Diana M, Miller Michael D, Mo Hongmei, Roberts Stuart K, O'Leary Jacqueline G, Shafran Stephen D, Zeuzem Stefan

Abstract excerpt

BACKGROUND & AIMS: The fixed-dose combination of sofosbuvir/velpatasvir was highly efficacious in patients infected with genotype (GT)1-6 hepatitis C virus (HCV) in the ASTRAL studies. This analysis evaluated the impact of baseline resistance-associated substitutions (RASs) on treatment outcome and emergence of RASs in patients infected with HCV GT1-6 who were treated with sofosbuvir/velpatasvir. METHODS:...

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Identifiers

PMID: 29221887
DOI: 10.1016/j.jhep.2017.11.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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