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CRISPR/Cas9 delivery with one single adenoviral vector devoid of all viral genes

1 Dec 2017

Abstract excerpt

The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 system revolutionized the field of gene editing but viral delivery of the CRISPR/Cas9 system has not been fully explored. Here we adapted clinically relevant high-capacity adenoviral vectors (HCAdV) devoid of all viral genes for the delivery of the CRISPR/Cas9 machinery using a single viral vector. We present a platform enabling fast...

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PMID: 29215041
DOI: 10.1038/s41598-017-17180-w

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