Article
A Role of NKR-P1A (CD161) and Lectin-like Transcript 1 in Natural Cytotoxicity against Human Articular Chondrocytes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2018
Białoszewska Agata, Olkowska-Truchanowicz Joanna, Bocian Katarzyna, Osiecka-Iwan Anna, Czop Andrzej, Kieda Claudine, Malejczyk Jacek
Abstract excerpt
Normal cartilage cells are susceptible to lysis by NK cells. This phenomenon may play a role in immune cartilage destruction; however, the mechanisms of chondrocyte recognition by NK cells remain poorly understood. Therefore, the aim of this study was to reveal a possible role of NKR-P1A/lectin-like transcript 1 (LLT1) interaction in NK cell-mediated cytotoxicity against normal human articular chondrocytes....
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