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Article

A functional SNP in the 3'-UTR of TAP2 gene interacts with microRNA hsa-miR-1270 to suppress the gene expression.

Environmental and molecular mutagenesis - 1 Mar 2018

Knox Bridgett, Wang Yong, Rogers Lora J, Xuan Jiekun, Yu Dianke, Guan Huaijin, Chen Jiwei, Shi Tieliu, Ning Baitang, Kadlubar Susan A

Abstract excerpt

The transporter associated with antigen processing 2 (TAP2) is involved in the development of multidrug resistance and the etiology of immunological diseases. In this study, we investigated whether the expression of TAP2 can be perturbed by single nucleotide polymorphisms (SNPs) located in 3'-untranslated region (3'-UTR) of the gene via interactions with microRNAs. Using a series of in silico assays, we selected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29205500
DOI: 10.1002/em.22159
PMCID: PMC5811321

Genes

TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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