Article
Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank.
Translational psychiatry - 30 Nov 2017
Howard David M, Hall Lynsey S, Hafferty Jonathan D, Zeng Yanni, Adams Mark J, Clarke Toni-Kim, Porteous David J, Nagy Reka, Hayward Caroline, Smith Blair H, Murray Alison D, Ryan Niamh M, Evans Kathryn L, Haley Chris S, Deary Ian J, Thomson Pippa A, McIntosh Andrew M
Abstract excerpt
Genome-wide association studies using genotype data have had limited success in the identification of variants associated with major depressive disorder (MDD). Haplotype data provide an alternative method for detecting associations between variants in weak linkage disequilibrium with genotyped variants and a given trait of interest. A genome-wide haplotype association study for MDD was undertaken utilising a...
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