Article
Identification of novel E347Q and G362K amino acid substitutions in HN neutralization epitope and major antigenic difference in novel sub-genotype VIIj isolates.
Acta virologica - 1 Jan 2000
Mayahi V, Esmaelizad M
Abstract excerpt
Hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) plays a crucial role in induction of immune response against Newcastle disease infection. Mutation in residues 347 and 362 of HN linear antigenic site has been identified to be responsible for antigenic variations. Hence we...
Topics
- Amino Acid Motifs
- Amino Acid Substitution
- Animals
- Antigenic Variation
- Antigens, Viral
- Chickens
- Epitopes
- Genotype
- HN Protein
- Hemagglutination Inhibition Tests
- Neutralization Tests
- Newcastle Disease
- Newcastle disease virus
- Poultry Diseases