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Article

The PB2-K627E mutation attenuates H3N2 swine influenza virus in cultured cells and in mice.

Research in veterinary science - 1 Apr 2018

Gong Xiao-Qian, Ruan Bao-Yang, Liu Xiao-Min, Zhang Peng, Wang Xiu-Hui, Wang Qi, Shan Tong-Ling, Tong Wu, Zhou Yan-Jun, Li Guo-Xin, Zheng Hao, Tong Guang-Zhi, Yu Hai

Abstract excerpt

PB2-627K is an important amino acid that determines the virulence of some influenza A viruses. However, it has not been experimentally investigated in the H3N2 swine influenza virus. To explore the potential role of PB2-K627E substitution in H3N2 swine influenza virus, the growth properties and pathogenicity between H3N2 swine influenza virus and its PB2-K627E mutant were compared. For the first time, our results...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29175013
DOI: 10.1016/j.rvsc.2017.11.006

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