Gefitinib versus vinorelbine plus cisplatin as adjuvant treatment for stage II-IIIA (N1-N2) EGFR-mutant NSCLC (ADJUVANT/CTONG1104): a randomised, open-label, phase 3 study.

doi:10.1016/S1470-2045(17)30729-5

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Gefitinib versus vinorelbine plus cisplatin as adjuvant treatment for stage II-IIIA (N1-N2) EGFR-mutant NSCLC (ADJUVANT/CTONG1104): a randomised, open-label, phase 3 study.

The Lancet. Oncology - 1 Jan 2018

Zhong Wen-Zhao, Wang Qun, Mao Wei-Min, Xu Song-Tao, Wu Lin, Shen Yi, Liu Yong-Yu, Chen Chun, Cheng Ying, Xu Lin, Wang Jun, Fei Ke, Li Xiao-Fei, Li Jian, Huang Cheng, Liu Zhi-Dong, Xu Shun, Chen Ke-Neng, Xu Shi-Dong, Liu Lun-Xu, Yu Ping, Wang Bu-Hai, Ma Hai-Tao, Yan Hong-Hong, Yang Xue-Ning, Zhou Qing, Wu Yi-Long

Abstract excerpt

BACKGROUND: Cisplatin-based adjuvant chemotherapy is the standard of care for patients with resected stage II-IIIA non-small-cell lung cancer (NSCLC). RADIANT and SELECT trial data suggest patients with EGFR-mutant stage IB-IIIA resected NSCLC could benefit from adjuvant EGFR tyrosine kinase inhibitor treatment. We aimed to compare the efficacy of adjuvant gefitinib versus vinorelbine plus cisplatin in patients...

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PMID: 29174310
DOI: 10.1016/S1470-2045(17)30729-5

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EGFR

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