Article
Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty.
The Journal of clinical endocrinology and metabolism - 1 Feb 2018
Howard Sasha R, Guasti Leonardo, Poliandri Ariel, David Alessia, Cabrera Claudia P, Barnes Michael R, Wehkalampi Karoliina, O'Rahilly Stephen, Aiken Catherine E, Coll Anthony P, Ma Marcella, Rimmington Debra, Yeo Giles S H, Dunkel Leo
Abstract excerpt
Context: Self-limited delayed puberty (DP) is often associated with a delay in physical maturation, but although highly heritable the causal genetic factors remain elusive. Genome-wide association studies of the timing of puberty have identified multiple loci for age at menarche in females and voice break in males, particularly in pathways controlling energy balance. Objective/Main Outcome Measures: We sought to...
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