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Article

Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2018

Mann Karl, Roos Corey R, Hoffmann Sabine, Nakovics Helmut, Leménager Tagrid, Heinz Andreas, Witkiewitz Katie

Abstract excerpt

Randomized trials of medications for alcohol dependence (AD) often report no differences between active medications. Few studies in AD have tested hypotheses regarding which medication will work best for which patients (ie, precision medicine). The PREDICT study tested acamprosate and naltrexone vs placebo in 426 randomly assigned AD patients in a 3-month treatment. PREDICT proposed individuals whose drinking was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29154368
DOI: 10.1038/npp.2017.282
PMCID: PMC5809801

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