Article
The genomic landscape of pediatric myelodysplastic syndromes.
Nature communications - 16 Nov 2017
Schwartz Jason R, Ma Jing, Lamprecht Tamara, Walsh Michael, Wang Shuoguo, Bryant Victoria, Song Guangchun, Wu Gang, Easton John, Kesserwan Chimene, Nichols Kim E, Mullighan Charles G, Ribeiro Raul C, Klco Jeffery M
Abstract excerpt
Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here, we describe the somatic and germline changes of pediatric MDS using whole exome sequencing, targeted amplicon sequencing, and/or RNA-sequencing of 46 pediatric primary MDS patients. Our data show that, in contrast to adult MDS, Ras/MAPK...
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