CFTR Genotype and Maximal Exercise Capacity in Cystic Fibrosis: A Cross-sectional Study.

doi:10.1513/AnnalsATS.201707-570OC

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Article

CFTR Genotype and Maximal Exercise Capacity in Cystic Fibrosis: A Cross-sectional Study.

Annals of the American Thoracic Society - 1 Feb 2018

Radtke Thomas, Hebestreit Helge, Gallati Sabina, Schneiderman Jane E, Braun Julia, Stevens Daniel, Hulzebos Erik Hj, Takken Tim, Boas Steven R, Urquhart Don S, Lands Larry C, Tejero Sergio, Sovtic Aleksandar, Dwyer Tiffany, Petrovic Milos, Harris Ryan A, Karila Chantal, Savi Daniela, Usemann Jakob, Mei-Zahav Meir, Hatziagorou Elpis, Ratjen Felix, Kriemler Susi

Abstract excerpt

RATIONALE: Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in human skeletal muscle cells. Variations of CFTR dysfunction among patients with cystic fibrosis may be an important determinant of maximal exercise capacity in cystic fibrosis. Previous studies on the relationship between CFTR genotype and maximal exercise capacity are scarce and contradictory. OBJECTIVES: This study was...

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PMID: 29140739
DOI: 10.1513/AnnalsATS.201707-570OC

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CFTR

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