Article
Transcriptome-wide association study of inflammatory biologic age.
Aging - 11 Nov 2017
Lin Honghuang, Lunetta Kathryn L, Zhao Qiang, Rong Jian, Benjamin Emelia J, Mendelson Michael M, Joehanes Roby, Levy Daniel, Larson Martin G, Murabito Joanne M
Abstract excerpt
Chronic low grade inflammation is a fundamental mechanism of aging. We estimated biologic age using nine biomarkers from diverse inflammatory pathways and we hypothesized that genes associated with inflammatory biological age would provide insights into human aging. In Framingham Offspring Study participants at examination 8 (2005 to 2008), we used the Klemera-Doubal method to estimate inflammatory biologic age...
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