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Interferon-γ-inducible protein 16 (IFI16) is required for the maintenance of Epstein-Barr virus latency

13 Nov 2017

Abstract excerpt

BACKGROUND: Epstein-Barr virus (EBV) exhibits both lytic and latent (Lat. I, II, and III) phases in an infected individual. It's during the latent phase of EBV that all EBV-associated cancers, including Burkitt's lymphoma, nasopharyngeal carcinoma and lymphoproliferative disease arise. Interferon-γ-inducible protein 16 (IFI16) is a well-established innate immune sensor and viral transcriptional regulator involved...

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PMID: 29132393
DOI: 10.1186/s12985-017-0891-5

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