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Null alleles and sequence variations at primer binding sites of STR loci within multiplex typing systems.

Legal medicine (Tokyo, Japan) - 1 Jan 2018

Yao Yining, Yang Qinrui, Shao Chengchen, Liu Baonian, Zhou Yuxiang, Xu Hongmei, Zhou Yueqin, Tang Qiqun, Xie Jianhui

Abstract excerpt

Rare variants are widely observed in human genome and sequence variations at primer binding sites might impair the process of PCR amplification resulting in dropouts of alleles, named as null alleles. In this study, 5 cases from routine paternity testing using PowerPlex®21 System for STR genotyping were considered to harbor null alleles at TH01, FGA, D5S818, D8S1179, and D16S539, respectively. The dropout of...

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PMID: 29125964
DOI: 10.1016/j.legalmed.2017.10.007

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FGA

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