MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma.

doi:10.1053/j.gastro.2017.10.043

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Article

MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma.

Gastroenterology - 1 Mar 2018

Lampis Andrea, Carotenuto Pietro, Vlachogiannis Georgios, Cascione Luciano, Hedayat Somaieh, Burke Rosemary, Clarke Paul, Bosma Else, Simbolo Michele, Scarpa Aldo, Yu Sijia, Cole Rebecca, Smyth Elizabeth, Mateos Javier Fernández, Begum Ruwaida, Hezelova Blanka, Eltahir Zakaria, Wotherspoon Andrew, Fotiadis Nicos, Bali Maria Antonietta, Nepal Chirag, Khan Khurum, Stubbs Mark, Hahne Jens C, Gasparini Pierluigi, Guzzardo Vincenza, Croce Carlo M, Eccles Suzanne, Fassan Matteo, Cunningham David, Andersen Jesper B, Workman Paul, Valeri Nicola, Braconi Chiara

Abstract excerpt

BACKGROUND & AIMS: Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents are needed. We performed a screen to identify small-molecule compounds that are active against CCAs. Levels of microRNA 21 (MIR21 or miRNA21) are increased in CCAs. We investigated whether miRNA21 mediates resistance of CCA cells and organoids to HSP90 inhibitors. METHODS: We performed a high-throughput screen of...

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Identifiers

PMID: 29113809
DOI: 10.1053/j.gastro.2017.10.043
PMCID: PMC5863695

Genes

DNAJB5
IDH1
PBRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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