Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective Direct Toxicity of Cocaine on Fetal Mouse Neurons: Teratogenic Implications of Neurite and Apoptotic Neuronal Loss

1 Jun 1998

Abstract excerpt

This chapter reviews epidemiologic clinical surveys and experimental animal studies, indicating that cocaine may induce severe teratogenic effects on the developing brain. Evidence for direct toxic effects is next presented. Using cocultures of embryonic brain cells, we demonstrate that cocaine selectively affects neuronal cells, first causing a dramatic reduction in the number and length of neurites, then...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neonatal and fetal brain pathology
Share to Neurogenesis and neuroplasticity mechanisms
Share to Prenatal Substance Exposure Effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29087597
DOI: 10.1111/j.1749-6632.1998.tb09726.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective Direct Toxicity of Cocaine on Fetal Mouse Neurons: Teratogenic Implications of Neurite and Apoptotic Neuronal LossPMID 29087597Read ↗

Drug‐induced Apoptotic Neurodegeneration in the Developing BrainSemantic proximity Read ↗

A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by CocaineSemantic proximity Read ↗

Teratogenic Effects of Alcohol on Brain DevelopmentSemantic proximity Read ↗

HIV-1 Tat neurotoxicity in primary cultures of rat midbrain fetal neurons: Changes in dopamine transporter binding and immunoreactivitySemantic proximity Read ↗

Developmental neurotoxicity: do similar phenotypes indicate a common mode of action? A comparison of fetal alcohol syndrome, toluene embryopathy and maternal phenylketonuria.Semantic proximity Read ↗

PRENATAL EXPOSURE TO AMPHETAMINESSemantic proximity Read ↗

Cigarette smoke induced neural tube defects by down‐regulating noggin expressionSemantic proximity Read ↗

Expression of mu-, kappa- and delta-opioid receptors in P19 mouse embryonal carcinoma cells.Semantic proximity Read ↗

Altered neuron-glia interactions in a low, chronic prenatal ethanol exposure.Semantic proximity Read ↗

Enhanced glutamatergic phenotype of mesencephalic dopamine neurons after neonatal 6-hydroxydopamine lesion.Semantic proximity Read ↗

Ethanol increases cholinergic and decreases GABAergic neuronal expression in cultures derived from 8-day-old chick embryo cerebral hemispheres: interaction of ethanol and growth factors.Semantic proximity Read ↗

Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.