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Massive dysregulation of genes involved in cell signaling and placental development in cloned cattle conceptus and maternal endometrium

8 Dec 2016

Abstract excerpt

A major unresolved issue in the cloning of mammals by somatic cell nuclear transfer (SCNT) is the mechanism by which the process fails after embryos are transferred to the uterus of recipients before or during the implantation window. We investigated this problem by using RNA sequencing (RNA-seq) to compare the transcriptomes in cattle conceptuses produced by SCNT and artificial insemination (AI) at day (d) 18...

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PMID: 27940919
DOI: 10.1073/pnas.1520945114

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