Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2018

Tang Ling, Zeng Jun, Geng Pengyu, Fang Chengnan, Wang Yang, Sun Mingju, Wang Changsong, Wang Jiao, Yin Peiyuan, Hu Chunxiu, Guo Lei, Yu Jane, Gao Peng, Li Enyou, Zhuang Zhengping, Xu Guowang, Liu Yang

Abstract excerpt

Purpose: Metabolic reprogramming is frequently identified in hepatocellular carcinoma (HCC), which is the most common type of liver malignancy. The reprogrammed cellular metabolisms promote tumor cell survival, proliferation, angiogenesis, and metastasis. However, the mechanisms of this process remain unclear in HCC.Experimental Design: The global nontargeted metabolic study in 69 paired hepatic carcinomas and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Energy Metabolism
Share to Hypoxia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Metabolome

Share to Metabolomics

Share to Proline

Share to Sorafenib

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 29084919
DOI: 10.1158/1078-0432.CCR-17-1707

Genes

PRODH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.PMID 29084919Read ↗

Characterization of the metabolic alteration-modulated tumor microenvironment mediated by TP53 mutation and hypoxia.Semantic proximity Read ↗

Integrative multiomics analysis identifies molecular subtypes and potential targets of hepatocellular carcinomaSemantic proximity Read ↗

ATF4 programs proline-dependent immune evasion in β-Catenin-driven hepatocellular carcinomaSemantic proximity Read ↗

Genomic and Transcriptomic Profile of HNF1A-Mutated Liver Adenomas Highlights Molecular Signature and Potential Therapeutic Implications.Semantic proximity Read ↗

Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesisSemantic proximity Read ↗

Deep Proteome Profiling Enabled Functional Annotation and Data-Independent Quantification of Proline Hydroxylation TargetsSemantic proximity Read ↗

Metabolomics profiling in plasma samples from glioma patients correlates with tumor phenotypes.Semantic proximity Read ↗

Identification of the Consistently Altered Metabolic Targets in Human Hepatocellular CarcinomaSemantic proximity Read ↗

Metabolic Profiling of Formalin-Fixed Paraffin-Embedded Tissues Discriminates Normal Colon from Colorectal CancerSemantic proximity Read ↗

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrixSemantic proximity Read ↗

Tissue-Based Metabolomics to Analyze the Breast Cancer Metabolome.Semantic proximity Read ↗

Proline Oxidase Functions as a Mitochondrial Tumor Suppressor in Human CancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.