Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy.

doi:10.1158/1078-0432.CCR-17-2335

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Article

Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2018

Morrow Matthew P, Kraynyak Kimberly A, Sylvester Albert J, Dallas Michael, Knoblock Dawson, Boyer Jean D, Yan Jian, Vang Russell, Khan Amir S, Humeau Laurent, Sardesai Niranjan Y, Kim J Joseph, Plotkin Stanley, Weiner David B, Trimble Cornelia L, Bagarazzi Mark L

Abstract excerpt

Purpose: As previously reported, treatment of high-grade cervical dysplasia with VGX-3100 resulted in complete histopathologic regression (CR) concomitant with elimination of HPV16/18 infection in 40.0% of VGX-3100-treated patients compared with only 14.3% in placebo recipients in a randomized phase IIb study. Here, we identify clinical and immunologic characteristics that either predicted or correlated with...

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PMID: 29084917
DOI: 10.1158/1078-0432.CCR-17-2335
PMCID: PMC6956401

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