Article
Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese.
Acta biochimica et biophysica Sinica - 1 Dec 2012
Zhao Jiuhan, Wang Xiaohong, Xu Jialiang, Li Nan, Shang Xiuli, He Zhiyi, Yang Jun
Abstract excerpt
Atherosclerosis is an important pathophysiological basis of atherothrombotic stroke (ATS), and inflammation plays a significant role in atherosclerosis formation. In this study, single-nucleotide polymorphisms (SNPs) in three key inflammation-related genes, 5-lipoxygenase activating protein (ALOX5AP), phosphodiesterase 4D (PDE4D), and interleukin-1α (IL-1α), were investigated to determine their association with...
Topics
- 5-Lipoxygenase-Activating Proteins
- Aged
- Alleles
- Asian People
- Atherosclerosis
- Brain Ischemia
- China
- Cyclic Nucleotide Phosphodiesterases, Type 3
- Cyclic Nucleotide Phosphodiesterases, Type 4
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype