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Article

Both Sphingomyelin and Cholesterol in the Host Cell Membrane Are Essential for Rubella Virus Entry.

Journal of virology - 1 Jan 2018

Otsuki Noriyuki, Sakata Masafumi, Saito Kyoko, Okamoto Kiyoko, Mori Yoshio, Hanada Kentaro, Takeda Makoto

Abstract excerpt

Rubella virus (RuV) causes a systemic infection, and transplacental fetal infection causes congenital rubella syndrome. In this study, we showed that treatment of cells with sphingomyelinase inhibited RuV infection. Assays using inhibitors of serine palmitoyl transferase and ceramide transport protein demonstrated the contribution of sphingomyelin (SM) to RuV infection. Compelling evidence for direct binding of...

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Source

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Identifiers

PMID: 29070689
DOI: 10.1128/JVI.01130-17
PMCID: PMC5730775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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