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Article

G protein-coupled estrogen receptor regulates embryonic heart rate in zebrafish.

PLoS genetics - 1 Oct 2017

Romano Shannon N, Edwards Hailey E, Souder Jaclyn Paige, Ryan Kevin J, Cui Xiangqin, Gorelick Daniel A

Abstract excerpt

Estrogens act by binding to estrogen receptors alpha and beta (ERα, ERβ), ligand-dependent transcription factors that play crucial roles in sex differentiation, tumor growth and cardiovascular physiology. Estrogens also activate the G protein-coupled estrogen receptor (GPER), however the function of GPER in vivo is less well understood. Here we find that GPER is required for normal heart rate in zebrafish...

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Identifiers

PMID: 29065151
DOI: 10.1371/journal.pgen.1007069
PMCID: PMC5669493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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