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Article

AKT1low Quiescent Cancer Cells Promote Solid Tumor Growth

23 Oct 2017

Abstract excerpt

Abstract Human tumor growth depends on rapidly dividing cancer cells driving population expansion. Even advanced tumors, however, contain slowly proliferating cancer cells for reasons that remain unclear. Here, we selectively disrupt the ability of rapidly proliferating cancer cells to spawn AKT1low daughter cells that are rare, slowly proliferating, tumor-initiating, and chemotherapy-resistant, using β1-integrin...

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PMID: 29054988
DOI: 10.1158/1535-7163.mct-16-0868

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