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Article

Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies.

Clinical and experimental pharmacology & physiology - 1 Mar 2018

Wu Shu-Zhi, Ye Hua, Yang Xiao-Guo, Lu Zhi-Li, Qu Qiang, Qu Jian

Abstract excerpt

Epilepsy is a common complex neurological disorder, and some forms are resistant to drug treatment. The HCN1/HCN2 genes encode hyperpolarization-activated cyclic nucleotide-gated channels, which play important roles in the electrophysiology of neurons. We investigated the association between HCN1/HCN2 variants and drug resistance or the risk of genetic generalized epilepsies (GGEs). We used matrix-assisted laser...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29047147
DOI: 10.1111/1440-1681.12877

Genes

HCN2
HCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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