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Article

In Silico Analyses Reveal the Relationship Between SIX1/EYA1 Mutations and Conotruncal Heart Defects.

Pediatric cardiology - 1 Jan 2018

Li Bojian, Xu Lijuan, Hong Nanchao, Chen Sun, Xu Rang

Abstract excerpt

Conotruncal heart defects (CTDs) represent a group of severe and complicated congenital cardiovascular malformations and require opportune clinical interventions once diagnosed. Occurrence of CTD is related to the functional abnormality of the second heart field (SHF), and variants of genes which regulate the development of the second heart field have been recognized as the main genetic factors leading to CTDs....

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Source

Identifiers

PMID: 29043394
DOI: 10.1007/s00246-017-1744-0

Genes

EYA1
SIX1
SHF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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