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Article

Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae.

Antimicrobial agents and chemotherapy - 1 Dec 2017

Sun Dongxu, Rubio-Aparicio Debora, Nelson Kirk, Dudley Michael N, Lomovskaya Olga

Abstract excerpt

Vaborbactam (formerly RPX7009) is a new β-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Klebsiella pneumoniaecarbapenemases (KPC). It has been developed in combination with meropenem. The objective of these studies was to identify the concentrations of both agents associated with the selection or prevention of single-step mutations leading to reduced...

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Identifiers

PMID: 29038260
DOI: 10.1128/AAC.01694-17
PMCID: PMC5700310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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