Article
Induced pluripotent stem cells derived from an autosomal dominant lateral temporal epilepsy (ADLTE) patient carrying S473L mutation in leucine-rich glioma inactivated 1 (LGI1).
Stem cell research - 1 Oct 2017
Tan Ghee Wan, Kondo Takayuki, Murakami Nagahisa, Imamura Keiko, Enami Takako, Tsukita Kayoko, Shibukawa Ran, Funayama Misato, Matsumoto Riki, Ikeda Akio, Takahashi Ryosuke, Inoue Haruhisa
Abstract excerpt
Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited epileptic syndrome, and it is associated with mutations of leucine-rich glioma inactivated 1 (LGI1) gene. The underlying mechanisms of ADLTE are still unknown, as human neurons are difficult to obtain as a research tool. Human induced pluripotent stem cells (iPSCs) allow the generation of patient-derived neuronal cells in a dish, and can be a...
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