Article
Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10.
Cytokine - 1 Apr 2018
Wada Taizo, Toma Tomoko, Miyazawa Hanae, Koizumi Eiko, Shirahashi Tetsujiro, Matsuda Yusuke, Yachie Akihiro
Abstract excerpt
BACKGROUND: Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene. Mutations in exon 10 are associated with typical FMF phenotypes, and patients with exon 10 mutations have higher serum levels of interleukin (IL)-18 both during attacks and afebrile phases, compared to those without exon 10 mutations. However, longitudinal changes of serum IL-18 in FMF have not been...
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