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Article

Specific Unbinding Forces Between Mutated Human P-Selectin Glycoprotein Ligand-1 and Viral Protein-1 Measured Using Force Spectroscopy.

The journal of physical chemistry letters - 2 Nov 2017

Wang Chen-Chu, Sivashanmugan Kundan, Chen Chung-Ku, Hong Jian-Ren, Sung Wei-I, Liao Jiunn-Der, Yang Yuh-Shyong

Abstract excerpt

Protein tyrosine sulfation (PTS) is a key modulator of extracellular protein-protein interaction (PPI), which regulates principal biological processes. For example, the capsid protein VP1 of enterovirus 71 (EV71) specifically interacts with sulfated P-selectin glycoprotein ligand-1 (PSGL-1) to facilitate virus invasion. Currently available methods cannot be used to directly observe PTS-induced PPI. In this study,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29016136
DOI: 10.1021/acs.jpclett.7b02373

Genes

PTS

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