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Article

Targeted Genomic Profiling Reveals Recurrent KRAS Mutations in Mesonephric-like Adenocarcinomas of the Female Genital Tract.

The American journal of surgical pathology - 1 Feb 2018

Mirkovic Jelena, McFarland Marie, Garcia Elizabeth, Sholl Lynette M, Lindeman Neal, MacConaill Laura, Dong Fei, Hirsch Michelle, Nucci Marisa R, Quick Charles M, Crum Christopher P, McCluggage W Glenn, Howitt Brooke E

Abstract excerpt

Mesonephric adenocarcinoma most commonly arises in the cervix and is presumed to be derived from normal or hyperplastic mesonephric remnants. It is characterized by recurrent KRAS mutations and lack of PIK3CA/PTEN alterations. Adenocarcinomas of the uterine corpus and ovary characterized by morph...

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Identifiers

PMID: 28984674
DOI: 10.1097/PAS.0000000000000958

Genes

KRAS
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-28984674-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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