Article
c-KIT Analysis and Targeted Molecular Sequencing of Mesonephric Carcinomas of the Female Genital Tract.
The American journal of surgical pathology - 1 Apr 2020
Pors Jennifer, Ho Julie, Prentice Leah, Thompson Emily, Cochrane Dawn, Gibbard Evan, Huntsman David, Gilks Blake, Hoang Lynn N
Abstract excerpt
Mesonephric carcinoma is a rare malignancy, thought to derive from Wolffian remnants. To date, no targeted molecular therapeutic options have been identified. On the basis of limited case reports, c-KIT immunohistochemical expression has been reported in female adnexal tumors of Wolffian origin, and targeted therapy with Imatinib has been attempted with mixed success. Currently, it is unclear whether c-KIT...
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