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Article

Proteolytic activation of Bacillus thuringiensis Vip3Aa protein by Spodoptera exigua midgut protease.

International journal of biological macromolecules - 1 Feb 2018

Zhang Jing, Pan Zhi-Zhen, Xu Lian, Liu Bo, Chen Zheng, Li Jie, Niu Li-Yang, Zhu Yu-Jing, Chen Qing-Xi

Abstract excerpt

Proteolysis of Vip3Aa by insect midgut proteases is essential for their toxicity against target insects. In the present study, proteolysis of Vip3Aa was evaluated by Spodoptera exigua midgut proteases (MJ). Trypsin was verified involved in the activation of Vip3Aa and three potential cleavage sites (Lys195, Lys197 and Lys198) were identified. Four Vip3Aa mutants (KKK195197198AAA, KK197198AA, KK195198AA and...

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PMID: 28970168
DOI: 10.1016/j.ijbiomac.2017.09.101

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